Mission of the Oklahoma Nathan Shock Center


We aim to serve as a national resource to enable sustained, accelerated progress in aging and geroscience research. We achieve this goal by providing intellectual leadership to the aging and geroscience research community and cutting-edge technology, innovation, training, mentorship and career development opportunities to investigators in these fields. In doing so, we advance our understanding of aging and expand the geroscience field. 


The Oklahoma NSC integrates resources across the three major research institutions in Oklahoma City: the University of Oklahoma Health Sciences, the Oklahoma Medical Research Foundation, and the Oklahoma City VA Health Care System. Working closely with other NSCs and the NSC Coordinating Center (NSC3) as well as other NIA- and NIH-funded Center programs, we help advance NIA’s goal to extend healthy, active years of life.

Administrative / Program Enrichment Core
Administrative / Program Enrichment Core

Provides leadership and coordination for the Center and builds the statewide geroscience community.

  • Center leadership and program coordination
  • Evaluation of the Center's impact
  • Geroscience webinar series and annual symposium
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Research Development Core
Research Development Core

Supports investigators who are new to aging research or building new directions in it.

  • Pilot award funding
  • Mentoring and training workshops
  • Public outreach
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Multiplexing Protein Analysis Core
Multiplexing Protein Analysis Core

Uses mass spectrometry to measure many proteins at once in tissues and cells.

  • Targeted panels of proteins
  • Development of new protein assays
  • Protein turnover measurements
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Genomic Sciences Core
Genomic Sciences Core

Provides sequencing-based analysis of the genome and its modifications.

  • DNA modification analysis by nanopore sequencing
  • Mitochondrial genome sequencing
  • Mitochondrial DNA copy number
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Geroscience Redox Biology Core
Geroscience Redox Biology Core

Measures oxidative stress and mitochondrial function in aging models.

  • Redox status and oxidative damage
  • Mitochondrial function and free radicals
  • TCA cycle intermediates
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CRISPR Whole Genome Screening Core
CRISPR Whole Genome Screening Core

Identifies genes that drive aging phenotypes using genome-wide screens.

  • Cell-based aging assays
  • Genome-wide CRISPR screens
  • Bioinformatic analysis and validation of candidate genes
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Oklahoma Nathan Shock Center of Excellence in Aging Research

940 Stanton L Young Blvd, BSMB Ste 853

Oklahoma City, OK 73104 

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